About Cathepsin S & Autoimmune Diseases

Cathepsin S plays a key role in the pathology of autoimmune disease and in the maintenance of neuropathic pain. Genetic and pharmacologic inhibition of cathepsin S results in amelioration of disease in pharmacology models.

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Cathepsin S inhibitor: VBY-129

VBY-129 is a potent, competitive and reversible inhibitor of purified cathepsin S. It is also highly selective against other human cathepsins (B, F, L, K and V). VBY-129 has potent activity in cellular assays and in animal models of disease.

A Phase 1 clinical trial of VBY-129 was completed which demonstrated sustained inhibition of cathepsin S after once daily oral dosing.

Once-daily dosing of VBY-129 achieves target concentration for inhibition of cathepsin S and blocks invariant chain processing in PBMCs from Phase I subjects

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Autoimmune Disease Indications